Plscr1 Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of viral genome replication; and phosphatidylserine biosynthetic process. Acts upstream of or within myeloid cell differentiation; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytosol; nucleus; and plasma membrane. Is expressed in hindgut; midgut; renal calyx; and renal pelvis. Orthologous to human PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plscr1 |
| Official Name | phospholipid scramblase 1 [Source:MGI Symbol;Acc:MGI:893575] |
| Ensembl ID | ENSMUSG00000032369 |
| Bio databases IDs | |
| Aliases | phospholipid scramblase 1 |
| Synonyms | MmTRA1a, MmTRA1b, Nor1, Phospholipid scramblase 1, Tra1, Tra1a, Tra1b, Tras1, Tras2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plscr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- viral receptor
- nuclease
- epidermal growth factor receptor binding
- calcium ion binding
- metal ion binding
- enzyme binding
- protein binding
- magnesium ion binding
- SH3-domain binding
- LURP-one-related
- CD4 receptor binding
- zinc ion binding
- phospholipid scramblase
- mercury ion binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- granulocytosis
role in cell
- growth
- apoptosis
- cell death
- differentiation
- quantity
- number
- activation
- colony formation
- size
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- membrane vesicles
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
- extracellular matrix
- membrane rafts