Plcg1

Enables glutamate receptor binding activity; phosphatidylinositol-4,5-bisphosphate phospholipase C activity; and receptor tyrosine kinase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within T cell receptor signaling pathway and in utero embryonic development. Located in cell-cell junction. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Plcg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcg1 gene, providing context for its role in the cell.