Abl1 Gene Summary [Mouse]
Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of cell migration; and regulation of T cell activation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; lymphocyte differentiation; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and leukemia (multiple). Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Abl1 |
| Official Name | c-abl oncogene 1, non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:87859] |
| Ensembl ID | ENSMUSG00000026842 |
| Bio databases IDs | |
| Aliases | c-abl oncogene 1, non-receptor tyrosine kinase |
| Synonyms | ABL, ABL proto-oncogene 1, non-receptor tyrosine kinase, BCR-ABL, c-ABL, CABL1, c-abl oncogene 1, non-receptor tyrosine kinase, CHDSKM, E430008G22Rik, JTK7, LOC100909750, p145Abl, p150, v-abl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- P1 loop domain
- protein-tyrosine kinase
- enzyme activator activity
- activation loop
- syntaxin binding
- Src homology 2 (SH2) domain
- GTP binding motif, P-loop
- transmembrane receptor
- RNA Pol II CTD binding domain
- protein kinase binding
- nuclear export signal
- DNA binding domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- SH2-domain binding
- protein kinase C binding
- phosphotyrosine binding
- protein binding
- F-actin binding
- magnesium ion binding
- sequence-specific DNA binding
- SH3-domain binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- actin-binding domain
- A loop
- tyrosine kinase domain
- protein kinase
- transcription co-activator
- ATP-binding domain
- DNA secondary structure binding
- caspase cleavage site
- ATP binding
- ephrin receptor binding
- Protein kinase domain
- proline rich domain
- Sh3 domain binding motif
- ligand-binding domain
- SH1 domain
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- nuclear localization sequence
- enzyme binding
- non-membrane spanning protein tyrosine kinase
- protein domain specific binding
- receptor binding
- autophosphorylation site
- phosphorylation site
- Src Homology 3 domain superfamily
- SH2-catalytic domain linker
- actin filament binding
- F-actin binding domain
- Protein Kinases, catalytic domain
- actin monomer binding
- double-stranded DNA binding
- manganese ion binding
- pro domain
Pathways
Biological processes and signaling networks where the Abl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- B Cell Receptor Signaling
- Bladder Cancer Signaling
- Caveolar-mediated Endocytosis Signaling
- CDK5 Signaling
- Cyclins and Cell Cycle Regulation
- DNA Double-Strand Break Repair by Homologous Recombination
- Ephrin Receptor Signaling
- G Protein Signaling Mediated by Tubby
- Glioma Signaling
- IL-15 Production
- Integrin Signaling
- Non-Small Cell Lung Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- PDGF Signaling
- Prostate Cancer Signaling
- Small Cell Lung Cancer Signaling
- Sperm Motility
- Telomerase Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- hematological system tumor
- neoplasia
- soft tissue sarcoma
- metastatic non-small cell lung cancer
- metastatic soft tissue sarcoma
- non-Hodgkin disease
- cancer
- hematological neoplasia
- malignant neoplasm
role in cell
- migration
- invasion
- apoptosis
- differentiation
- activation in
- production in
- cell death
- organization
- binding in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- glutaminergic synapse
- ruffle
- podosome rosette
- Cytoplasm
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- Endoplasmic Reticulum
- flagella
- Mitochondria
- cytosol
- apical cell surfaces
- endoplasmic reticulum membrane
- nucleoplasm
- nucleoli
- nuclear bodies
- acrosome
- growth cone
- neurites
- rough endoplasmatic reticulum
- cell membrane leading edge
- perikaryon
- dendrites
- postsynaptic density
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell-cell adhesion
- post-embryonic development
- signal transduction in response to DNA damage
- positive regulation of cell migration involved in sprouting angiogenesis
- mitochondrial depolarization
- positive regulation of interferon-gamma production
- regulation of microtubule polymerization
- negative regulation of endothelial cell apoptotic process
- establishment of localization in cell
- neuron apoptotic process
- activated T cell proliferation
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- platelet-derived growth factor receptor-beta signaling pathway
- negative regulation of mitotic cell cycle
- DNA damage response, signal transduction resulting in induction of apoptosis
- positive regulation of substrate adhesion-dependent cell spreading
- mismatch repair
- response to DNA damage stimulus
- positive regulation of mitotic cell cycle
- positive regulation of T cell migration
- regulation of actin cytoskeleton organization
- positive regulation of focal adhesion assembly
- positive regulation of stress fiber assembly
- response to endoplasmic reticulum stress
- negative regulation of long-term synaptic potentiation
- Bergmann glial cell differentiation
- cellular senescence
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- spleen development
- response to xenobiotic stimulus
- Fc-gamma receptor signaling pathway involved in phagocytosis
- alpha-beta T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- mitotic cell cycle
- positive regulation of neuron apoptotic process
- thymus development
- integrin-mediated signaling pathway
- positive regulation of fibroblast proliferation
- B-1 B cell homeostasis
- substrate adhesion-dependent cell spreading
- positive regulation of endothelial cell migration
- T cell receptor signaling pathway
- positive regulation of peptidyl-tyrosine phosphorylation
- B cell receptor signaling pathway
- negative regulation of cellular senescence
- peptidyl-tyrosine autophosphorylation
- positive regulation of release of sequestered calcium ion into cytosol
- I-kappaB kinase/NF-kappaB cascade
- negative regulation of BMP signaling pathway
- regulation of axon extension
- positive regulation of protein phosphorylation
- regulation of cell motility
- peptidyl-tyrosine phosphorylation
- protein modification process
- neuroepithelial cell differentiation
- negative regulation of double-strand break repair via homologous recombination
- epidermal growth factor receptor signaling pathway
- protein autophosphorylation
- endothelial cell migration
- associative learning
- B cell proliferation involved in immune response
- negative regulation of ubiquitin-protein ligase activity
- autophagy
- BMP signaling pathway
- regulation of cell cycle
- regulation of endocytosis
- regulation of Cdc42 protein signal transduction
- positive regulation of osteoblast proliferation
- neuron differentiation
- cardiac muscle cell proliferation
- transitional one stage B cell differentiation
- cerebellum morphogenesis
- regulation of T cell differentiation
- cellular response to transforming growth factor beta stimulus
- myoblast proliferation
- regulation of autophagy
- neuromuscular process controlling balance
- positive regulation of vasoconstriction
- protein phosphorylation
- response to oxidative stress
- response to epinephrine stimulus
- neural tube closure
- cellular response to hydrogen peroxide
- positive regulation of interleukin-2 production
- actin filament polymerization
- regulation of transcription, DNA-dependent
- positive regulation of dendrite development
- elevation of cytosolic calcium ion concentration
- ERK1 and ERK2 cascade
- cellular response to lipopolysaccharide
- positive regulation of oxidoreductase activity
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- cellular response to oxidative stress
- DNA conformation change
- microspike assembly
- regulation of cell adhesion
- negative regulation of protein serine/threonine kinase activity
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nuclear body
- neuronal cell body
- nucleolus
- plasma membrane
- nucleoplasm
- growth cone
- dendrite
- nucleus
- nuclear membrane
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- ruffle
- actin cytoskeleton
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ephrin receptor binding
- supercoiled DNA binding
- magnesium ion binding
- phosphotyrosine binding
- proline-rich region binding
- ATP binding
- nicotinate-nucleotide adenylyltransferase activity
- protein tyrosine kinase activity
- non-membrane spanning protein tyrosine kinase activity
- manganese ion binding
- SH3 domain binding
- protein kinase C binding
- syntaxin binding
- bubble DNA binding
- protein kinase activity
- SH2 domain binding
- four-way junction DNA binding
- actin monomer binding
- actin filament binding
- delta-catenin binding
- DNA binding
- protein binding
- transcription coactivator activity
- mitogen-activated protein kinase binding
- kinase activity