Plac8 Gene Summary [Mouse]
Enables chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of transcription by RNA polymerase II; and response to cold. Predicted to be located in nucleoplasm. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver lobe; and prostate gland lobe. Orthologous to human PLAC8 (placenta associated 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plac8 |
| Official Name | placenta-specific 8 [Source:MGI Symbol;Acc:MGI:2445289] |
| Ensembl ID | ENSMUSG00000029322 |
| Bio databases IDs | |
| Aliases | placenta-specific 8 |
| Synonyms | C15, D5Wsu111e, DGIC, LOC100910270, Onzin, placenta associated 8, placenta-specific 8, PNAS-144 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plac8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
- PLAC8 family
- zDHHC ankyrin repeat binding domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Plac8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- septic shock
- lymphomagenesis
- weight gain
- hepatocellular carcinoma
- central nervous system cancer
- major depression
- cervical cancer
- COVID-19
role in cell
- survival
- apoptosis
- growth
- expression in
- proliferation
- G2/M phase
- number
- function
- autophagy in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- azurophil granule lumen
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plac8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- response to cold
- brown fat cell differentiation
- negative regulation of apoptotic process
- positive regulation of cell proliferation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- chromatin binding