Trim59 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in host-mediated suppression of symbiont invasion. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and skin. Orthologous to human TRIM59 (tripartite motif containing 59). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim59 |
| Official Name | tripartite motif-containing 59 [Source:MGI Symbol;Acc:MGI:1914199] |
| Ensembl ID | ENSMUSG00000034317 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 59 |
| Synonyms | 2310035M22Rik, 2700022F13Rik, IFT80L, MRF1, RGD1311956, RNF104, TRIM57, tripartite motif-containing 59, TSBF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim59 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Stage III sporulation protein AF (Spore_III_AF)
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma formation
- androgenic alopecia
- growth failure
- Huntington disease
- lung adenocarcinoma
- hemorrhoid
- gastrulation failure
role in cell
- phosphorylation in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim59 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral entry into host cell
- innate immune response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding