Arpp21 Gene Summary [Mouse]
Predicted to enable calmodulin binding activity and nucleic acid binding activity. Acts upstream of or within cellular response to heat. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; limb segment; sensory organ; and tail. Orthologous to human ARPP21 (cAMP regulated phosphoprotein 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arpp21 |
| Official Name | cyclic AMP-regulated phosphoprotein, 21 [Source:MGI Symbol;Acc:MGI:107562] |
| Ensembl ID | ENSMUSG00000032503 |
| Bio databases IDs | |
| Aliases | cyclic AMP-regulated phosphoprotein, 21 |
| Synonyms | 0710001E13Rik, cAMP regulated phosphoprotein 21, cyclic AMP-regulated phosphoprotein, 21, D9Bwg1012e, LOC102553309, Ppp1r1c, Ppp1r1cl, R3HDM3, RCS, RGD1307208, RGD1307215, TARPP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arpp21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUZ domain
- R3H
- R3H domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- ion channel
disease
- Huntington disease
- pervasive developmental disorder
- myelodysplastic bone marrow neoplasm
- myelodysplastic syndrome
- neuroticism
- amyotrophic lateral sclerosis
- neurotic disorder
- vertigo
role in cell
- differentiation
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arpp21 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- calmodulin binding