Gatad2b Gene Summary [Mouse]
Predicted to enable sequence-specific DNA binding activity and zinc ion binding activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of NuRD complex. Is expressed in early conceptus and genitourinary system. Used to study GAND syndrome. Human ortholog(s) of this gene implicated in GAND syndrome. Orthologous to human GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gatad2b |
| Official Name | GATA zinc finger domain containing 2B [Source:MGI Symbol;Acc:MGI:2443225] |
| Ensembl ID | ENSMUSG00000042390 |
| Bio databases IDs | |
| Aliases | GATA zinc finger domain containing 2B |
| Synonyms | C430014D17Rik, GANDS, GATA zinc finger domain containing 2B, KIAA1150, mKIAA1150, MRD18, p66, P66beta, p68, RGD1308533 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gatad2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Coiled-coil and interaction region of P66A and P66B with MBD2
- protein binding
- ZnF_GATA
Pathways
Biological processes and signaling networks where the Gatad2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- epithelial cancer
- autosomal dominant mental retardation type 18
- hereditary disorder
- mental retardation
- pervasive developmental disorder
- conduct disorder
- prostatic carcinoma
- male pattern hair loss
role in cell
- expression in
- migration
- quantity
- remodeling
- binding in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gatad2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of cell fate specification
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear speck
- NuRD complex
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- nucleosomal DNA binding
- sequence-specific DNA binding