Syde1 Gene Summary [Mouse]
Enables GTPase activator activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; synaptic vesicle docking; and synaptonemal complex assembly. Located in cerebellar mossy fiber; cytosol; and synaptic membrane. Is expressed in labyrinthine zone; placenta; spongiotrophoblast; trophectoderm; and trophoblast giant cell. Orthologous to human SYDE1 (synapse defective Rho GTPase homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syde1 |
| Official Name | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) [Source:MGI Symbol;Acc:MGI:1918959] |
| Ensembl ID | ENSMUSG00000032714 |
| Bio databases IDs | |
| Aliases | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) |
| Synonyms | 1200008N06RIK, 7h3, BB043000, mSYD1A, RGD1305857, SYD1, synapse defective 1, Rho GTPase, homolog 1 (C. elegans), synapse defective Rho GTPase homolog 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syde1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase regulator
- binding protein
- GTPase activator
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synaptic membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syde1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of cytoskeleton organization
- regulation of Ras protein signal transduction
- cell migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- synaptic membrane
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- GTPase regulator activity