Ovol2 Gene Summary [Mouse]
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; positive regulation of keratinocyte differentiation; and tube morphogenesis. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ovol2 |
| Official Name | ovo like zinc finger 2 [Source:MGI Symbol;Acc:MGI:1338039] |
| Ensembl ID | ENSMUSG00000037279 |
| Bio databases IDs | |
| Aliases | ovo like zinc finger 2 |
| Synonyms | 1700108N11Rik, 1810007D21Rik, CHED, CHED1, CHED2, EUROIMAGE566589, hOvo2, M-OVO, movo2, M-OVO-A, M-OVO-B, Ovo2, ovo-like zinc finger 2, PPCD1, Zfp339, ZNF339 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ovol2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- posterior polymorphous corneal dystrophy type 1
- skin barrier defect
- growth failure
- bleeding
role in cell
- expression in
- production in
- proliferation
- migration
- cell death
- invasion by
- differentiation
- epithelial-mesenchymal transition
- cell cycle progression
- instability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ovol2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- cell proliferation
- negative regulation of SMAD protein import into nucleus
- embryonic digestive tract morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- endocardium formation
- heart trabecula formation
- regulation of transcription from RNA polymerase II promoter
- dorsal/ventral pattern formation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- epidermal cell differentiation
- negative regulation of epithelial to mesenchymal transition
- neural fold formation
- neural crest cell migration
- labyrinthine layer blood vessel development
- angiogenesis
- negative regulation of stem cell proliferation
- regulation of keratinocyte proliferation
- positive regulation of gene expression
- heart looping
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity