SYDE1 Gene Summary [Human]
The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]
Details
| Type | Protein Coding |
| Official Symbol | SYDE1 |
| Official Name | synapse defective Rho GTPase homolog 1 [Source:HGNC Symbol;Acc:HGNC:25824] |
| Ensembl ID | ENSG00000105137 |
| Bio databases IDs | |
| Aliases | synapse defective Rho GTPase homolog 1 |
| Synonyms | 1200008N06RIK, 7h3, BB043000, mSYD1A, RGD1305857, SYD1, synapse defective 1, Rho GTPase, homolog 1 (C. elegans), synapse defective Rho GTPase homolog 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYDE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase regulator
- binding protein
- GTPase activator
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synaptic membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYDE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of cytoskeleton organization
- regulation of Ras protein signal transduction
- cell migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- synaptic membrane
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- GTPase regulator activity