Cby1 Gene Summary [Mouse]
Predicted to enable beta-catenin binding activity and protein homodimerization activity. Involved in cardiac muscle cell differentiation and fat cell differentiation. Acts upstream of or within cilium assembly; floor plate development; and negative regulation of canonical Wnt signaling pathway. Located in centriole and ciliary basal body. Is expressed in heart; liver; lung; and olfactory epithelium. Used to study otitis media and primary ciliary dyskinesia. Orthologous to human CBY1 (chibby 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cby1 |
| Official Name | chibby family member 1, beta catenin antagonist [Source:MGI Symbol;Acc:MGI:1920989] |
| Ensembl ID | ENSMUSG00000022428 |
| Bio databases IDs | |
| Aliases | chibby family member 1, beta catenin antagonist |
| Synonyms | 1110014P06Rik, arb1, C22orf2, CBY, Chibby1, chibby 1, beta catenin antagonist, chibby 1, β catenin antagonist, chibby family member 1, beta catenin antagonist, chibby family member 1, β catenin antagonist, HS508I15A, PGEA1, PGEA14, PIGEA-14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cby1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding
- Cby_like
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Joubert syndrome type 1
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
- anemia
- sinusitis
- hypoplasia
- otitis media
- weight gain
- infection by bacteria
role in cell
- phosphorylation in
- abnormal morphology
- differentiation
- adipogenesis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- Nucleus
- basal bodies
- centrosome
- centriole
- cytoplasmic aggregates
- cytosol
- apical cell surfaces
- trans Golgi network
- nucleoplasm
- nucleoli
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cby1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- protein homotetramerization
- cilium morphogenesis
- negative regulation of transcription, DNA-dependent
- protein localization
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- fat cell differentiation
- floor plate development
- cardiac muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- centriole
- cilium basal body
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- beta-catenin binding