Slc8b1 Gene Summary [Mouse]
Enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential and protein homodimerization activity. Involved in calcium export from the mitochondrion; intracellular calcium ion homeostasis; and regulation of lymphocyte chemotaxis. Acts upstream of or within mitochondrial calcium ion transmembrane transport and sodium ion transmembrane transport. Located in mitochondrion and plasma membrane. Is expressed in forelimb bud. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc8b1 |
| Official Name | solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 [Source:MGI Symbol;Acc:MGI:2180781] |
| Ensembl ID | ENSMUSG00000032754 |
| Bio databases IDs | |
| Aliases | solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
| Synonyms | NCKX6, NCLX, SLC24A6, solute carrier family 8 member B1, solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc8b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium:sodium antiporter
- calcium:cation antiporter
- protein homodimerization
- Sodium/calcium exchanger protein
- identical protein binding
- ion channel
- transporter
Pathways
Biological processes and signaling networks where the Slc8b1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial multiple sclerosis
- neurodegeneration
regulates
- Ca2+
- D-glucose
- insulin
- ion
- Na+
- lithium
- L-glutamic acid
role in cell
- cell death
- proliferation
- transport in
- degeneration
- transmembrane potential
- shortening
- healing
- regulation
- shortening in
- dynamics in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc8b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell membrane potential
- regulation of insulin secretion
- ion transport
- glucose homeostasis
- mitochondrial calcium ion homeostasis
- cytosolic calcium ion homeostasis
- sodium ion transmembrane transport
- mitochondrial calcium ion transport
- regulation of store-operated calcium entry
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrial crista
- sarcolemma
- membrane
- plasma membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- calcium:cation antiporter activity
- protein homodimerization activity
- calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
- calcium:sodium antiporter activity