Rangrf Gene Summary [Mouse]
Enables several functions, including guanyl-nucleotide exchange factor activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in regulation of membrane depolarization and regulation of sodium ion transmembrane transporter activity. Located in intercalated disc and nucleoplasm. Is expressed in central nervous system; retina; retina ganglion cell layer; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human RANGRF (RAN guanine nucleotide release factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rangrf |
| Official Name | RAN guanine nucleotide release factor [Source:MGI Symbol;Acc:MGI:1889073] |
| Ensembl ID | ENSMUSG00000032892 |
| Bio databases IDs | |
| Aliases | RAN guanine nucleotide release factor |
| Synonyms | 2400006H24Rik, HSPC165, HSPC236, MOG1, RANGNRF, RAN guanine nucleotide release factor, RGD1563195 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rangrf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel regulator
- guanyl-nucleotide exchange factor
- Mog1
- ion channel binding
- enzyme binding
- sodium channel regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Brugada syndrome
- atrial ventricular block
- brugada syndrome type 8
- ventricular tachycardia
- cardiac fibrosis
- ventricular extrasystole
regulates
- Na+
role in cell
- proliferation
- transmembrane potential
- depolarization
- abnormal morphology
- assembly
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intercellular junctions
- cytosol
- caveolae
- nucleoplasm
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rangrf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart rate
- ER to Golgi vesicle-mediated transport
- regulation of membrane potential
- heart contraction
- protein exit from endoplasmic reticulum
- positive regulation of protein localization at cell surface
- protein import into nucleus
- regulation of sodium ion transmembrane transporter activity
- regulation of membrane depolarization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- perinuclear region of cytoplasm
- cytoplasm
- rough endoplasmic reticulum
- intercalated disc
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- ion channel binding