Pctp Gene Summary [Mouse]
Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within cholesterol metabolic process. Located in cytosol. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; intestine; liver; and stomach. Orthologous to human PCTP (phosphatidylcholine transfer protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pctp |
| Official Name | phosphatidylcholine transfer protein [Source:MGI Symbol;Acc:MGI:107375] |
| Ensembl ID | ENSMUSG00000020553 |
| Bio databases IDs | |
| Aliases | phosphatidylcholine transfer protein |
| Synonyms | Phosphatidylcholine transfer, phosphatidylcholine transfer protein, STARD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pctp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- phospholipid binding
- phosphatidylcholine transporter
- binding protein
- alpha helix
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- weight gain
- allergic rhinitis
- productive infection by HIV-1
role in cell
- apoptosis
- abnormal morphology
- function
- transactivation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pctp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- phospholipid transport
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylcholine binding
- phosphatidylcholine transporter activity