Muc20 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within hepatocyte growth factor receptor signaling pathway and positive regulation of MAPK cascade. Predicted to be located in basal plasma membrane; cytosol; and mitochondrial outer membrane. Is expressed in lung; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human MUC20 (mucin 20, cell surface associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Muc20 |
| Official Name | mucin 20 [Source:MGI Symbol;Acc:MGI:2385039] |
| Ensembl ID | ENSMUSG00000035638 |
| Bio databases IDs | |
| Aliases | mucin 20 |
| Synonyms | BC026367, KIAA1359, MUCIN 20, mucin 20, cell surface associated |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- liver cancer
- hepatoblastoma
role in cell
- migration
- invasion by
- cell viability
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cytosol
- basal membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hepatocyte growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- basal plasma membrane
- Golgi lumen
- extracellular region
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding