RANGRF Gene Summary [Human]
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | RANGRF |
| Official Name | RAN guanine nucleotide release factor [Source:HGNC Symbol;Acc:HGNC:17679] |
| Ensembl ID | ENSG00000108961 |
| Bio databases IDs | |
| Aliases | RAN guanine nucleotide release factor, MOG1 homolog (S. cerevisiae) |
| Synonyms | 2400006H24Rik, HSPC165, HSPC236, MOG1, RANGNRF, RAN guanine nucleotide release factor, RGD1563195 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RANGRF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel regulator
- guanyl-nucleotide exchange factor
- Mog1
- ion channel binding
- enzyme binding
- sodium channel regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Brugada syndrome
- atrial ventricular block
- brugada syndrome type 8
- ventricular tachycardia
- cardiac fibrosis
- ventricular extrasystole
regulates
role in cell
- proliferation
- transmembrane potential
- depolarization
- abnormal morphology
- assembly
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intercellular junctions
- cytosol
- caveolae
- nucleoplasm
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RANGRF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart rate
- ER to Golgi vesicle-mediated transport
- regulation of membrane potential
- heart contraction
- protein exit from endoplasmic reticulum
- positive regulation of protein localization at cell surface
- protein import into nucleus
- regulation of sodium ion transmembrane transporter activity
- regulation of membrane depolarization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- perinuclear region of cytoplasm
- cytoplasm
- rough endoplasmic reticulum
- intercalated disc
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- ion channel binding