Chpf Gene Summary [Mouse]
Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Acts upstream of or within chondroitin sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; cerebral cortex; and humerus. Orthologous to human CHPF (chondroitin polymerizing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chpf |
| Official Name | chondroitin polymerizing factor [Source:MGI Symbol;Acc:MGI:106576] |
| Ensembl ID | ENSMUSG00000032997 |
| Bio databases IDs | |
| Aliases | chondroitin polymerizing factor |
| Synonyms | 1700028N03Rik, chondroitin polymerizing factor, CHPF1, CHSY2, CSS2, D1BWG1363E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chpf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
- Chondroitin N-acetylgalactosaminyltransferase
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
- enzyme
- protein binding
- glycosyltransferase
- glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioma
- glioma formation
- androgenic alopecia
- aortic valve calcification
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
regulates
- calpain large catalytic subunit
role in cell
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chpf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- Golgi cisterna membrane
- cytosol
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
- metal ion binding
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity