Trip11 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; inner ear receptor cell stereocilium organization; and ventricular septum development. Located in acrosomal membrane and cis-Golgi network. Is expressed in cranium. Used to study achondrogenesis type IA. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trip11 |
| Official Name | thyroid hormone receptor interactor 11 [Source:MGI Symbol;Acc:MGI:1924393] |
| Ensembl ID | ENSMUSG00000021188 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 11 |
| Synonyms | 2610511G22Rik, 3110031G15Rik, 6030460N08RIK, ACG1A, AI450776, CEV14, GMAP-210, ODCD, ODCD1, THR COACTIVATOR, thyroid hormone receptor interactor 11, TRIP230 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trip11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- transcription regulator
- exonuclease SbcC
- transcription co-activator
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- basic Helix Loop Helix (bHLH) domain superfamily
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- GRAB domain
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- thyroid hormone receptor binding domain
- HOOK protein coiled-coil region
Pathways
Biological processes and signaling networks where the Trip11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- odontochondrodysplasia 1
- achondrogenesis type IA
- connective tissue disorder
- myeloid/lymphoid neoplasm with eosinophilia
- hematological neoplasia
- androgenic alopecia
- TRIP11-related skeletal dysplasia
regulates
- reporter gene
- VEGF
- DNA endogenous promoter
- RNA polymerase II
- DNA promoter
- AHR/ARNT/aryl hydrocarbon
- CYP1A1
role in cell
- formation
- organization
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cilia
- perichromosomal region
- cellular membrane
- Nucleus
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- Golgi membrane
- cis Golgi networks
- acrosome
- transport vesicles
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trip11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- inner ear receptor stereocilium organization
- chondrocyte differentiation involved in endochondral bone morphogenesis
- ER to Golgi vesicle-mediated transport
- positive regulation of transcription, DNA-dependent
- Golgi organization
- ventricular septum development
- protein glycosylation
- transcription from RNA polymerase II promoter
- Golgi ribbon formation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- cytoskeleton
- outer acrosomal membrane
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- transport vesicle
- inner acrosomal membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- small GTPase binding