Clec1b Gene Summary [Mouse]
Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within platelet formation. Located in cell surface and plasma membrane. Is expressed in dorsal root ganglion; liver; lung; and spinal cord. Orthologous to human CLEC1B (C-type lectin domain family 1 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec1b |
| Official Name | C-type lectin domain family 1, member b [Source:MGI Symbol;Acc:MGI:1913287] |
| Ensembl ID | ENSMUSG00000030159 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 1, member b |
| Synonyms | 1810061I13Rik, CLEC2, CLEC2B, C-type lectin domain family 1 member B, C-type lectin domain family 1, member B, PRO1384, QDED721, RGD1563517 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hemITAM motif
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- rheumatoid arthritis
- epithelial neoplasia
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- disease-specific survival
- deep vein thrombosis
- testicular seminoma
- seminomatous testicular cancer
role in cell
- formation
- expression in
- function
- proliferation
- migration
- secretion
- activation
- cell viability
- aggregation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- membrane surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- platelet formation
- cell surface receptor signaling pathway
- defense response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- carbohydrate binding