Ucp2 Gene Summary [Mouse]
Enables GDP binding activity. Involved in several processes, including cellular response to glucose stimulus; macrophage differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ucp2 |
| Official Name | uncoupling protein 2 (mitochondrial, proton carrier) [Source:MGI Symbol;Acc:MGI:109354] |
| Ensembl ID | ENSMUSG00000033685 |
| Bio databases IDs | |
| Aliases | uncoupling protein 2 (mitochondrial, proton carrier) |
| Synonyms | BMIQ4, SLC25A8, UCPH, uncoupling protein 2, Uncoupling protein 2, mitochondrial, uncoupling protein 2 (mitochondrial, proton carrier) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ucp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- oxaloacetate transporter
- malate transporter
- Mitochondrial carrier protein
- protein binding
- chloride transporter
- inorganic phosphate transporter
- GDP binding
- sulfate porter
- aspartate transporter
- antiporter
- protein homodimerization
- uniporter
- transporter
Pathways
Biological processes and signaling networks where the Ucp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- metastasis
- weight gain
- diabetes mellitus
- obesity
- insulin-dependent diabetes mellitus
- peripheral arterial disease
- Hutchinson-Gilford progeria syndrome
- Huntington disease
- nonalcoholic fatty liver disease
role in cell
- quantity
- expression in
- activation in
- proliferation
- phosphorylation in
- signaling in
- growth
- production in
- function
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ucp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of insulin secretion involved in cellular response to glucose stimulus
- C4-dicarboxylate transport
- cellular response to amino acid starvation
- glycolysis
- glutamine metabolic process
- response to superoxide
- mitochondrial fission
- negative regulation of neuron apoptotic process
- cellular response to lead ion
- cellular response to insulin stimulus
- response to cold
- reactive oxygen species metabolic process
- long-chain fatty acid transport
- response to hypoxia
- regulation of mitochondrial membrane potential
- cellular response to glucose stimulus
- response to fatty acid
- malate transmembrane transport
- L-aspartate transport
- macrophage differentiation
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- secondary active sulfate transmembrane transporter activity
- protein homodimerization activity
- protein binding
- hydrogen ion transmembrane transporter activity
- antiporter activity
- oxaloacetate transmembrane transporter activity
- GDP binding
- malate transmembrane transporter activity
- oxidative phosphorylation uncoupler activity
- L-aspartate transmembrane transporter activity
- chloride transmembrane transporter activity