TR/RXR Activation
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Thyroid hormone affects a range of biological processes such as growth, development and metabolism. The biologically active form of the hormone is triiodothyronine (T3); it acts through nuclear receptors TR (thyroid receptor) alpha and beta. TR is usually found as a heterodimer with RXR. Binding of T3 to TR releases the repressor complex from the TR-RXR heterodimer. T3 bound TR-RXR along with a number of co-activators can then regulate gene expression...
Pathway Summary
Thyroid hormone affects a range of biological processes such as growth, development and metabolism. The biologically active form of the hormone is triiodothyronine (T3); it acts through nuclear receptors TR (thyroid receptor) alpha and beta. TR is usually found as a heterodimer with RXR. Binding of T3 to TR releases the repressor complex from the TR-RXR heterodimer. T3 bound TR-RXR along with a number of co-activators can then regulate gene expression. TR is also involved in a non-genomic action through activation of PI3K pathway. Perturbation of thyroid hormone and its receptors affects various processes including lipid metabolism, carbohydrate metabolism, steroid metabolism, thermogenesis and CNS function.
TR/RXR Activation Genes list
Explore Genes related to TR/RXR Activation
AKR1C1
Human
aldo-keto reductase family 1 member C1
AKR1C2
Human
aldo-keto reductase family 1 member C2
AKR1C3
Human
aldo-keto reductase family 1 member C3
ATP2A1
Human
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
CAMK4
Human
calcium/calmodulin dependent protein kinase IV
CAMP
Human
cathelicidin antimicrobial peptide
COL6A3
Human
collagen type VI alpha 3 chain
CYP7A1
Human
cytochrome P450 family 7 subfamily A member 1
G6PC1
Human
glucose-6-phosphatase catalytic subunit 1
HIF1A
Human
hypoxia inducible factor 1 subunit alpha
LDLR
Human
low density lipoprotein receptor
MTOR
Human
mechanistic target of rapamycin kinase
PCK1
Human
phosphoenolpyruvate carboxykinase 1
PIK3C2A
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
PIK3C2B
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
PIK3C2G
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
PIK3C3
Human
phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3CA
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
PIK3CG
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
PIK3R1
Human
phosphoinositide-3-kinase regulatory subunit 1
PIK3R2
Human
phosphoinositide-3-kinase regulatory subunit 2
PIK3R3
Human
phosphoinositide-3-kinase regulatory subunit 3
PIK3R4
Human
phosphoinositide-3-kinase regulatory subunit 4
PIK3R5
Human
phosphoinositide-3-kinase regulatory subunit 5
PIK3R6
Human
phosphoinositide-3-kinase regulatory subunit 6
RAB3B
Human
RAB3B, member RAS oncogene family
SCARB1
Human
scavenger receptor class B member 1
SLC16A2
Human
solute carrier family 16 member 2
SLC16A3
Human
solute carrier family 16 member 3
SLC2A1
Human
solute carrier family 2 member 1
SREBF1
Human
sterol regulatory element binding transcription factor 1
SREBF2
Human
sterol regulatory element binding transcription factor 2
STRBP
Human
spermatid perinuclear RNA binding protein
TBL1Y
Human
transducin beta like 1 Y-linked
TSHB
Human
thyroid stimulating hormone subunit beta
Products related to TR/RXR Activation
Explore products related to TR/RXR Activation
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