Smyd5 Gene Summary [Mouse]
Enables histone H3K36 trimethyltransferase activity and histone H4K20 methyltransferase activity. Involved in regulation of stem cell differentiation; regulation of stem cell division; and transposable element silencing by heterochromatin formation. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; heart; hemolymphoid system; incisor; and skeletal musculature. Orthologous to human SMYD5 (SMYD family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smyd5 |
| Official Name | SET and MYND domain containing 5 [Source:MGI Symbol;Acc:MGI:108048] |
| Ensembl ID | ENSMUSG00000033706 |
| Bio databases IDs | |
| Aliases | SET and MYND domain containing 5 |
| Synonyms | AW536703, Mgc29044, NN8-4AG, RAI15, RRG1, SET and MYND domain containing 5, SMYD family member 5, ZMYND23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smyd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-lysine N-methyltransferase
- histone lysine N-methyltransferase activity (H4-K20 specific)
- MYND finger
- histone lysine N-methyltransferase activity (H3-K36 specific)
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- liver cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- lung adenocarcinoma
- hepatocellular carcinoma
- lung adenocarcinoma formation
regulated by
- ANGPT2
- tretinoin
role in cell
- binding in
- differentiation
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smyd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- regulation of stem cell differentiation
- regulation of stem cell division
- methylation
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone methyltransferase activity (H4-K20 specific)