Cxcl10 Gene Summary [Mouse]
Predicted to enable chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; lacrimal gland; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cxcl10 |
| Official Name | chemokine (C-X-C motif) ligand 10 [Source:MGI Symbol;Acc:MGI:1352450] |
| Ensembl ID | ENSMUSG00000034855 |
| Bio databases IDs | |
| Aliases | chemokine (C-X-C motif) ligand 10 |
| Synonyms | C7, CRG-2, C-X-C motif chemokine ligand 10, gIP-10, Ifi10, INP10, IP-10, mob-1, Scyb10 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cxcl10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- chemoattractant
- Small cytokines (intecrine/chemokine), interleukin-8 like
- CXCR3 chemokine receptor binding
- cytokine
- heparin binding
Pathways
Biological processes and signaling networks where the Cxcl10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Communication between Innate and Adaptive Immune Cells
- Granulocyte Adhesion and Diapedesis
- IL-17A Signaling in Gastric Cells
- Neuroinflammation Signaling Pathway
- Pathogenesis of Multiple Sclerosis
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of MAPK Signaling in the Pathogenesis of Influenza
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- insulin-dependent diabetes mellitus
- Huntington disease
- delayed hypersensitive reaction
- multiorgan inflammation
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- demyelination
- dilated cardiomyopathy
role in cell
- cell viability
- accumulation
- activation
- proliferation
- binding
- chemotaxis
- cellular infiltration by
- invasion
- differentiation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular space
- plasma membrane extracellular face
- basal lamina
- exosomes