Dnah8 Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to be located in axoneme. Predicted to be part of outer dynein arm. Predicted to be active in sperm flagellum. Is expressed in brain and thymus primordium. Used to study spermatogenic failure 46. Human ortholog(s) of this gene implicated in spermatogenic failure 46. Orthologous to human DNAH8 (dynein axonemal heavy chain 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dnah8 |
| Official Name | dynein, axonemal, heavy chain 8 [Source:MGI Symbol;Acc:MGI:107714] |
| Ensembl ID | ENSMUSG00000033826 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, heavy chain 8 |
| Synonyms | ATPase, DLP8, Dnahc8, dynein axonemal heavy chain 8, dynein, axonemal, heavy chain 8, hdhc9, Hst6.7b, LOC102554931, LOC687540, P1-Loop, SPGF46 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnah8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynein heavy chain C-terminal domain
- ATP-binding dynein motor region
- Microtubule-binding stalk of dynein motor
- enzyme
- microtubule motor protein
- Dynein heavy chain, N-terminal region 1
- P-loop containing dynein motor region
- Dynein heavy chain, N-terminal region 2
- P-loop containing dynein motor region D4
- Dynein heavy chain AAA lid domain
- AAA domain (dynein-related subfamily)
- Dynein heavy chain region D6 P-loop domain
- Hydrolytic ATP binding site of dynein motor region
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- epithelial cancer
- primary ciliary dyskinesia
- hypospadia
- osteoarthritis
- spermatogenic failure 46
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- suicide attempt
regulates
- testosterone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axonemes
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnah8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- outer dynein arm assembly
- cilium movement involved in cell motility
- ciliary cell motility
Cellular Component
Where in the cell the gene product is active
- outer dynein arm
- axonemal dynein complex
- sperm flagellum
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- dynein light intermediate chain binding
- dynein intermediate chain binding
- minus-end-directed microtubule motor activity