Srrt Gene Summary [Mouse]
Enables DNA binding activity. Involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; liver; lung; retina; and spleen. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srrt |
| Official Name | serrate RNA effector molecule homolog (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1933527] |
| Ensembl ID | ENSMUSG00000037364 |
| Bio databases IDs | |
| Aliases | serrate RNA effector molecule homolog (Arabidopsis) |
| Synonyms | 2810019G02RIK, AABR07035787.1, ARS2, ASR2, ASR2A, ASR2B, ASR2C, ASR2D, LOC686980, serrate, serrate, RNA effector molecule, serrate RNA effector molecule homolog (Arabidopsis) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srrt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding activity, bridging
- protein binding
- Arsenite-resistance protein 2
- DNA binding
- SERRATE/Ars2, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- aortic valve calcification
- infection by HIV-1
role in cell
- formation
- apoptosis
- expression in
- binding in
- formation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srrt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- primary miRNA processing
- response to arsenic-containing substance
- regulation of transcription, DNA-dependent
- positive regulation of neurogenesis
- mRNA processing
- neuronal stem cell maintenance
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- protein binding, bridging