Rtn3 Gene Summary [Mouse]
Involved in endoplasmic reticulum tubular network formation. Is active in synapse. Is expressed in several structures, including genitourinary system; nervous system; olfactory epithelium; retina; and vibrissa. Used to study chronic kidney disease. Orthologous to human RTN3 (reticulon 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtn3 |
| Official Name | reticulon 3 [Source:MGI Symbol;Acc:MGI:1339970] |
| Ensembl ID | ENSMUSG00000024758 |
| Bio databases IDs | |
| Aliases | reticulon 3 |
| Synonyms | ASYIP, HAP, NSPL2, NSPLII, reticulon 3, RTN3-A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- lumenal/extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- fibrosis
- major depression
- Alzheimer disease
- microalbuminuria
- edema
- uterine leiomyoma
- leiomyomatosis
- glomerulosclerosis
- infection by HIV-1
role in cell
- quantity
- cellular infiltration by
- development
- formation
- thickness
- organization
- abnormal morphology
- formation in
- K63 polyubiquitination in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- presynaptic regions
- Extracellular Space
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- neurofilaments
- synaptic vesicles
- growth cone
- synapse
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- neuron differentiation
- apoptotic process
- endoplasmic reticulum tubular network assembly
- brain development
- endoplasmic reticulum tubular network organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- extracellular space
- Golgi apparatus
- endoplasmic reticulum
- Golgi membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding