Flvcr2 Gene Summary [Mouse]
Enables choline binding activity and choline transmembrane transporter activity. Involved in choline transport and transport across blood-brain barrier. Acts upstream of or within several processes, including endothelial tip cell fate specification; in utero embryonic development; and lung development. Is active in plasma membrane. Is expressed in several structures, including central nervous system and yolk sac. Used to study proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flvcr2 |
| Official Name | feline leukemia virus subgroup C cellular receptor 2 [Source:MGI Symbol;Acc:MGI:2384974] |
| Ensembl ID | ENSMUSG00000034258 |
| Bio databases IDs | |
| Aliases | feline leukemia virus subgroup C cellular receptor 2 |
| Synonyms | C14orf58, CCT, EPV, feline leukaemia virus subgroup C cellular receptor 2, feline leukemia virus subgroup C cellular receptor 2, FLVCR choline and putative heme transporter 2, FLVCRL14q, MFSD7C, PVHH, SLC49A2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flvcr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amine/polyamine transporter
- organic cation transporter
- binding protein
- organic alcohol transporter
- drug resistance transporter, EmrB/QacA subfamily
- Major Facilitator Superfamily
- choline transporter
- Na(+)-dependent inorganic phosphate cotransporter
- protein binding
- heme binding
- heme transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- endoplasmic reticulum membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flvcr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- heme export
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- heme transporter activity
- heme binding