Flvcr2 Gene Summary [Rat]
Predicted to enable several functions, including choline binding activity; heme binding activity; and organic cation transmembrane transporter activity. Predicted to be involved in choline transport; heme export; and transport across blood-brain barrier. Predicted to act upstream of or within several processes, including endothelial tip cell fate specification; in utero embryonic development; and lung development. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flvcr2 |
| Official Name | feline leukemia virus subgroup C cellular receptor family, member 2 [Source:RGD Symbol;Acc:735098] |
| Ensembl ID | ENSRNOG00000008754 |
| Bio databases IDs | |
| Aliases | feline leukemia virus subgroup C cellular receptor family, member 2 |
| Synonyms | C14orf58, CCT, EPV, feline leukaemia virus subgroup C cellular receptor 2, feline leukemia virus subgroup C cellular receptor 2, FLVCR choline and putative heme transporter 2, FLVCRL14q, MFSD7C, PVHH, SLC49A2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Flvcr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amine/polyamine transporter
- organic cation transporter
- binding protein
- organic alcohol transporter
- drug resistance transporter, EmrB/QacA subfamily
- Major Facilitator Superfamily
- choline transporter
- Na(+)-dependent inorganic phosphate cotransporter
- protein binding
- heme binding
- heme transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- endoplasmic reticulum membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Flvcr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- heme export
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- heme transporter activity
- heme binding