FLVCR2 Gene Summary [Human]
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | FLVCR2 |
| Official Name | FLVCR heme transporter 2 [Source:HGNC Symbol;Acc:HGNC:20105] |
| Ensembl ID | ENSG00000119686 |
| Bio databases IDs | |
| Aliases | FLVCR heme transporter 2 |
| Synonyms | C14orf58, CCT, EPV, feline leukaemia virus subgroup C cellular receptor 2, feline leukemia virus subgroup C cellular receptor 2, FLVCR choline and putative heme transporter 2, FLVCRL14q, MFSD7C, PVHH, SLC49A2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FLVCR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amine/polyamine transporter
- organic cation transporter
- binding protein
- organic alcohol transporter
- drug resistance transporter, EmrB/QacA subfamily
- Major Facilitator Superfamily
- choline transporter
- Na(+)-dependent inorganic phosphate cotransporter
- protein binding
- heme binding
- heme transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- endoplasmic reticulum membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FLVCR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- heme export
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- heme transporter activity
- heme binding