Stip1 Gene Summary [Mouse]
Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Acts upstream of or within cellular response to interleukin-7. Located in myelin sheath. Is active in nucleus. Is expressed in several structures, including central nervous system; liver; lung; metanephros; and notochord. Orthologous to human STIP1 (stress induced phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stip1 |
| Official Name | stress-induced phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:109130] |
| Ensembl ID | ENSMUSG00000024966 |
| Bio databases IDs | |
| Aliases | stress-induced phosphoprotein 1 |
| Synonyms | HEL-S-94n, HOP, IEF-SSP-3521, P60, SIP1, STI1, STI1L, Stress-induced phosphoprotein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Hsp70 protein binding
- Prp binding domain
- Tetratricopeptide repeats
- heat shock protein binding
- alpha helix
- chaperone binding
- STI1 domain
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Stip1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Waldenström macroglobulinemia
- Alzheimer disease
- acute inflammation
- multiple system atrophy
- ischemic injury
- rheumatoid arthritis
- colon carcinoma
- colon epithelial cancer
- obesity
role in cell
- binding
- loss
- cell death
- apoptosis
- survival
- proliferation
- activation in
- function
- loss in
- neuroprotection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- organelle
- cell surface
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stip1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- Hsp90 protein binding