Map2k3 Gene Summary [Mouse]
Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map2k3 |
| Official Name | mitogen-activated protein kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346868] |
| Ensembl ID | ENSMUSG00000018932 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase 3 |
| Synonyms | LOC100911550, LOC108348082, MAP KINASE KINASE 3B, MAPKK3, MEK3, mitogen-activated protein kinase kinase 3, MKK3, Mkk3b, PRKMK3, SAPKK-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map2k3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- protein threonine/tyrosine kinase
- protein kinase binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- docking domain
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map2k3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- AMPK Signaling
- BER pathway
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Endocannabinoid Developing Neuron Pathway
- ErbB Signaling
- FGF Signaling
- GADD45 Signaling
- HIF1α Signaling
- IL-10 Signaling
- IL-15 Production
- LPS-stimulated MAPK Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neurotrophin/TRK Signaling
- Polyamine Regulation in Colon Cancer
- Reelin Signaling in Neurons
- Role of IL-17A in Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- T Cell Receptor Signaling
- Toll-like Receptor Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- osteoporosis
- neoplasia
- myopathy
- tumorigenesis
- metastasis
- psoriasis
role in cell
- expression in
- activation
- binding in
- proliferation
- cell death
- apoptosis
- survival
- phosphorylation in
- activation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- cytosol
- nucleoplasm
- late endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map2k3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to sorbitol
- negative regulation of hippo signaling cascade
- p38MAPK cascade
- signal transduction
- stress-activated protein kinase signaling cascade
- cellular senescence
- positive regulation of MAPK cascade
- cardiac muscle contraction
- positive regulation of blood vessel endothelial cell migration
- MAPK cascade
- heart development
- inflammatory response
- response to ischemia
- positive regulation of nitric-oxide synthase biosynthetic process
- cellular response to lipopolysaccharide
- positive regulation of transcription, DNA-dependent
- positive regulation of protein kinase activity
- regulation of cytokine production
- cellular response to vascular endothelial growth factor stimulus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein tyrosine kinase activity
- protein binding
- MAP kinase kinase activity
- protein serine/threonine kinase activity