Gns Gene Summary [Mouse]
Enables N-acetylglucosamine-6-sulfatase activity. Involved in heparan sulfate proteoglycan catabolic process. Located in lysosome. Is expressed in several structures, including eye; nervous system; skeleton; and spleen primordium. Used to study mucopolysaccharidosis III. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gns |
| Official Name | glucosamine (N-acetyl)-6-sulfatase [Source:MGI Symbol;Acc:MGI:1922862] |
| Ensembl ID | ENSMUSG00000034707 |
| Bio databases IDs | |
| Aliases | glucosamine (N-acetyl)-6-sulfatase |
| Synonyms | 2610016K11RIK, G6S, glucosamine (N-acetyl)-6-sulfatase, glucosamine (N-acetyl)-6-sulphatase, LOC100909505, LOC688338, N-ACETYLGLUCOSAMINE-6-SULFATASE, N-ACETYLGLUCOSAMINE-6-sulphATASE, NACGLCN6S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gns often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- N-acetylglucosamine-6-sulfatase
- sulfuric ester hydrolase
- binding protein
- Sulfatase
- enzyme
- protein binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- mucopolysaccharidosis, mps-III-d
- neonatal late-onset sepsis
- Sanfilippo disease
regulates
- glycosaminoglycan
- heparan sulfate proteoglycan
- keratan sulfate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- lysosome
- lysosomal compartment
- azurophil granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gns gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratan sulfate catabolic process
- glycosaminoglycan catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- lysosomal lumen
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- glycosaminoglycan binding
- sulfuric ester hydrolase activity
- sulfate binding
- N-acetylglucosamine-6-sulfatase activity