Cep152 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Located in centrosome and deuterosome. Is expressed in several structures, including brain; lung; pharynx epithelium; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cep152 |
| Official Name | centrosomal protein 152 [Source:MGI Symbol;Acc:MGI:2139083] |
| Ensembl ID | ENSMUSG00000068394 |
| Bio databases IDs | |
| Aliases | centrosomal protein 152 |
| Synonyms | centrosomal protein 152, LOC102555758, MCPH4, MCPH9, mKIAA0912, RGD1305348, SCKL5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cep152 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, common bacterial type
- exonuclease SbcC
- protein kinase binding
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pericentriolar matrix
- organelle
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- nuclear bodies
- pro-centriole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cep152 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centriole replication
- centrosome duplication
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- centrosome
- centriole
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding