Mast4 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to be located in cytoplasm. Is expressed in brain; thymus primordium; and ventral grey horn. Used to study Sertoli cell-only syndrome. Orthologous to human MAST4 (microtubule associated serine/threonine kinase family member 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mast4 |
| Official Name | microtubule associated serine/threonine kinase family member 4 [Source:MGI Symbol;Acc:MGI:1918885] |
| Ensembl ID | ENSMUSG00000034751 |
| Bio databases IDs | |
| Aliases | microtubule associated serine/threonine kinase family member 4 |
| Synonyms | 4930420O11Rik, microtubule associated serine/threonine kinase family member 4, mKIAA0303, RGD1310139 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mast4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- canonical PDZ domain
- Protein kinase domain
- PDZ domain
- Domain of unknown function (DUF1908)
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- prostate cancer
- breast cancer
- coronary artery disease
- metabolic syndrome X
- colorectal cancer
- chronic lymphocytic leukemia
- bullous pemphigoid
- non-insulin-dependent diabetes mellitus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mast4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein serine/threonine kinase activity