Smad1

Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and primary miRNA binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; osteoblast differentiation; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including brain development; positive regulation of macromolecule biosynthetic process; and skeletal system development. Located in cytoplasm and nucleus. Part of homomeric SMAD protein complex and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human SMAD1 (SMAD family member 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Smad1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Smad1 gene, providing context for its role in the cell.