Scai Gene Summary [Mouse]
Enables transcription corepressor activity. Involved in negative regulation of Rho protein signal transduction and negative regulation of cell migration. Located in cytoplasm and nucleus. Is expressed in olfactory epithelium. Orthologous to human SCAI (suppressor of cancer cell invasion). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scai |
| Official Name | suppressor of cancer cell invasion [Source:MGI Symbol;Acc:MGI:2443716] |
| Ensembl ID | ENSMUSG00000035236 |
| Bio databases IDs | |
| Aliases | suppressor of cancer cell invasion |
| Synonyms | 9330112M16, A930041I02Rik, C9orf126, LOC100364814, LOC682319, NET40, suppressor of cancer cell invasion |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scai often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein SCAI
- transcription regulator
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- colorectal cancer
- neuroticism
- papillary thyroid carcinoma
- papillary thyroid cancer
- substance-related disorder
- depressive disorder
- overall survival
regulated by
- PTCSC3
- TP53BP1
- mir-574
- WNT3A
regulates
role in cell
- expression in
- migration
- formation
- formation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scai gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Rho protein signal transduction
- negative regulation of transcription, DNA-dependent
- transcription, DNA-dependent
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity