Cacng5 Gene Summary [Mouse]

Predicted to enable channel regulator activity and voltage-gated calcium channel activity. Predicted to be involved in several processes, including positive regulation of glutamatergic synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of AMPA receptor activity. Predicted to be located in postsynaptic density. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in nervous system and retina. Orthologous to human CACNG5 (calcium voltage-gated channel auxiliary subunit gamma 5). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cacng5
Official Name
calcium channel, voltage-dependent, gamma subunit 5 [Source:MGI Symbol;Acc:MGI:2157946]
Ensembl ID
ENSMUSG00000040373
Bio databases IDs NCBI: 140723 Ensembl: ENSMUSG00000040373
Aliases calcium channel, voltage-dependent, gamma subunit 5
Synonyms calcium channel, voltage-dependent, gamma subunit 5, calcium channel, voltage-dependent, γ subunit 5, calcium voltage-gated channel auxiliary subunit gamma 5, calcium voltage-gated channel auxiliary subunit γ 5, Calcng5, TARP gamma 5, TARP γ 5
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacng5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • voltage-gated calcium channel
  • ion transporter
  • PMP-22/EMP/MP20/Claudin family
  • protein binding
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • insomnia
regulated by
  • tretinoin
  • thioacetamide
  • phenacetin
  • hexachlorobenzene
  • indomethacin
  • cyclosporin A
  • lomustine
  • phenylbutazone
  • ethionine
  • vancomycin

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • microsomal fraction
  • glutaminergic synapse
  • cellular membrane
  • postsynaptic membrane
  • postsynaptic density
  • synaptosomal fractions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacng5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • calcium ion transmembrane transport
  • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
  • positive regulation of synaptic transmission, glutamatergic
  • transmission of nerve impulse

Cellular Component

Where in the cell the gene product is active
  • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
  • postsynaptic density

Molecular Function

What the gene product does at the molecular level
  • ion transmembrane transporter activity
  • voltage-gated calcium channel activity
  • channel regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.