Cnot3 Gene Summary [Mouse]
Involved in positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and white fat. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cnot3 |
| Official Name | CCR4-NOT transcription complex, subunit 3 [Source:MGI Symbol;Acc:MGI:2385261] |
| Ensembl ID | ENSMUSG00000035632 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex, subunit 3 |
| Synonyms | A930039N10RIK, CCR4-NOT transcription complex subunit 3, CCR4-NOT transcription complex, subunit 3, IDDSADF, KIAA0691, LENG2, NOT3, NOT3H |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnot3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NOT2 / NOT3 / NOT5 family
- Not1 N-terminal domain, CCR4-Not complex component
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoporosis
- metastasis
- lung squamous cell carcinoma
- squamous cell lung cancer
- intellectual developmental disorder with speech delay, autism, and dysmorphic facies
- hereditary disorder
- cardiac hypertrophy
- complex neurodevelopmental disorder
- lung adenocarcinoma
role in cell
- proliferation
- apoptosis
- expression in
- binding in
- phosphorylation in
- size
- differentiation
- transition
- number
- gefitinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnot3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of stem cell maintenance
- regulation of transcription, DNA-dependent
- gene silencing by RNA
- trophectodermal cell differentiation
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cytoplasmic mRNA processing body
- CCR4-NOT core complex
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- protein binding