CNOT3 Gene Summary [Human]
Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CNOT3 |
| Official Name | CCR4-NOT transcription complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:7879] |
| Ensembl ID | ENSG00000088038 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex subunit 3, NOT3 (negative regulator of transcription 3, yeast) homolog |
| Synonyms | A930039N10RIK, CCR4-NOT transcription complex subunit 3, CCR4-NOT transcription complex, subunit 3, IDDSADF, KIAA0691, LENG2, NOT3, NOT3H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNOT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NOT2 / NOT3 / NOT5 family
- Not1 N-terminal domain, CCR4-Not complex component
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoporosis
- metastasis
- lung squamous cell carcinoma
- squamous cell lung cancer
- intellectual developmental disorder with speech delay, autism, and dysmorphic facies
- hereditary disorder
- cardiac hypertrophy
- complex neurodevelopmental disorder
- lung adenocarcinoma
role in cell
- proliferation
- apoptosis
- expression in
- binding in
- phosphorylation in
- size
- differentiation
- transition
- number
- gefitinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNOT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of stem cell maintenance
- regulation of transcription, DNA-dependent
- gene silencing by RNA
- trophectodermal cell differentiation
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cytoplasmic mRNA processing body
- CCR4-NOT core complex
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- protein binding