Fxr2 Gene Summary [Mouse]
Predicted to enable mRNA 3'-UTR binding activity; protein dimerization activity; and translation regulator activity. Involved in dentate gyrus development and mRNA destabilization. Located in dendrite and ribosome. Is active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in central nervous system; female reproductive system; peripheral nervous system; sensory organ; and skin. Orthologous to human FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fxr2 |
| Official Name | fragile X mental retardation, autosomal homolog 2 [Source:MGI Symbol;Acc:MGI:1346074] |
| Ensembl ID | ENSMUSG00000018765 |
| Bio databases IDs | |
| Aliases | fragile X mental retardation, autosomal homolog 2 |
| Synonyms | FMR1 autosomal homolog 2, FMR1L2, FXR2H, FXR2P |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fxr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fragile X-related 1 protein core C terminal
- Fragile X-related 1 protein C-terminal region 2
- FMRP KH0 domain
- K homology RNA-binding domain
- protein binding
- identical protein binding
- RNA binding
- Fragile X mental retardation Tudor domain
- Tudor-like domain present in plant sequences
- KH domain
- K homology (KH) RNA-binding domain, type I
- protein homodimerization
- Agenet domain
- Tudor domain superfamily
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- schizophrenia
- motor dysfunction or movement disorder
- hyperactive behavior
role in cell
- expression in
- proliferation
- signaling in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- polyribosome fractions
- glutaminergic synapse
- postsynaptic region
- ribosome
- polysomes
- cytosol
- stress granule
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fxr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA destabilization
- positive regulation of translation
- organ development
- regulation of mRNA stability
- mRNA transport
- dentate gyrus development
- positive regulation of long-term neuronal synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- membrane
- cytosol
- neuron projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- translation regulator activity
- protein binding
- RNA binding
- protein homodimerization activity
- protein heterodimerization activity
- mRNA 3'-UTR binding