Dagla Gene Summary [Mouse]
Enables monoacylglycerol lipase activity. Involved in arachidonate metabolic process; regulation of neuroinflammatory response; and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Located in dendritic spine membrane and varicosity. Is active in postsynaptic membrane. Is expressed in brain and olfactory epithelium. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dagla |
| Official Name | diacylglycerol lipase, alpha [Source:MGI Symbol;Acc:MGI:2677061] |
| Ensembl ID | ENSMUSG00000035735 |
| Bio databases IDs | |
| Aliases | diacylglycerol lipase, alpha |
| Synonyms | C11orf11, Dagl, DAGLALPHA, DAGL(ALPHA), DAGL(α), diacylglycerol lipase alpha, diacylglycerol lipase, alpha, diacylglycerol lipase α, diacylglycerol lipase, α, NOC2, Nsc dendrite, NSDDR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dagla often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PPXXF motif
- alpha/beta hydrolases
- acylglycerol lipase
- enzyme
- protein binding
- hydrolase
- Lipase (class 3)
Pathways
Biological processes and signaling networks where the Dagla gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- metastasis
- epithelial cancer
- neoplasia
- psoriasis
- paroxysmal type neuroocular syndrome-2
- refractive error
- organismal death
- major depression
- anapyrexia
role in cell
- phosphorylation in
- expression in
- proliferation
- invasion by
- migration
- neurogenesis
- lenvatinib sensitivity
- activation in
- production in
- utilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- axon component
- presynaptic regions
- postsynaptic membrane
- synaptic membrane
- endosomal membrane
- dendritic spines
- dendritic spine head
- growth cone
- nerve ending
- filopodial tip
- axons
- dendrites
- axon terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dagla gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- diacylglycerol catabolic process
- neuroblast proliferation
- monoacylglycerol biosynthetic process
- G-protein coupled glutamate receptor signaling pathway
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite membrane
- varicosity
- cytoplasm
- postsynaptic membrane
- dendritic spine membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acylglycerol lipase activity
- protein binding
- metal ion binding
- lipoprotein lipase activity