Fzr1 Gene Summary [Mouse]
Predicted to enable anaphase-promoting complex binding activity; ubiquitin ligase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of cellular senescence and positive regulation of cell population proliferation. Acts upstream of or within lens fiber cell differentiation; proteolysis involved in protein catabolic process; and regulation of meiotic nuclear division. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fzr1 |
| Official Name | fizzy and cell division cycle 20 related 1 [Source:MGI Symbol;Acc:MGI:1926790] |
| Ensembl ID | ENSMUSG00000020235 |
| Bio databases IDs | |
| Aliases | fizzy and cell division cycle 20 related 1 |
| Synonyms | CDC20C, CDH1, Cdh1/Hct1 homolog, DEE109, fizzy and cell division cycle 20 related 1, FYR, FZR, FZR2, HCDH, HCDH1, HCT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fzr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- C-box domain
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
- cyclin-binding domain
- Fizzy domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the Fzr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- liver cancer
- cancer
- epithelial cancer
- hereditary disorder
- breast adenocarcinoma
- breast carcinoma
- breast cancer
- breast or ovarian cancer
role in cell
- binding in
- proliferation
- expression in
- cell death
- apoptosis
- accumulation in
- activation in
- growth
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fzr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- regulation of meiotic cell cycle
- mitotic cell cycle G2/M transition DNA damage checkpoint
- protein K11-linked ubiquitination
- positive regulation of cell proliferation
- regulation of meiosis
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- lens fiber cell differentiation
- regulation of mitotic cell cycle
- negative regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- anaphase-promoting complex binding