Cnr1 Gene Summary [Mouse]
Enables cannabinoid receptor activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in growth cone. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in heroin dependence; obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnr1 |
| Official Name | cannabinoid receptor 1 (brain) [Source:MGI Symbol;Acc:MGI:104615] |
| Ensembl ID | ENSMUSG00000044288 |
| Bio databases IDs | |
| Aliases | cannabinoid receptor 1 (brain) |
| Synonyms | CANN6, Cannabinoid cb1 receptor, Cannabinoid Receptor, cannabinoid receptor 1, CB1, CB1A, CB1B, CB1 cannabinoid receptor, CB1K5, CB1R, CB1 receptors, CB-R, CNR, CNR1 isoform 1, Gm3576, LOC100046242, SKR6R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- cannabinoid receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Cnr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- G-Protein Coupled Receptor Signaling
- Gαi Signaling
- Gαs Signaling
- Phagosome Formation
- Reelin Signaling in Neurons
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- colorectal cancer
- hepatic fibrosis
- epithelial neoplasia
- benign neoplasia
- hepatic steatosis
- adenoma formation
- gastrointestinal neoplasia
- Parkinson disease
- dyskinesia
role in cell
- apoptosis
- activation in
- phosphorylation in
- proliferation
- expression in
- accumulation
- fragmentation in
- cell death
- production in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- detergent-soluble membrane fractions
- membrane fraction
- synaptosomal membrane fractions
- glutaminergic synapse
- inhibitory bouton
- Cytoplasm
- synaptic cleft
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- inner membrane
- actin cytoskeleton
- Nucleus
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- granules
- presynaptic membrane
- growth cone
- neurites
- nerve ending
- axon initial segments
- synaptosomes
- synapse
- multivesicular bodies
- rough endoplasmatic reticulum
- membrane rafts
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of serotonin secretion
- regulation of penile erection
- memory
- axonal fasciculation
- response to ethanol
- regulation of insulin secretion
- negative regulation of fatty acid beta-oxidation
- regulation of metabolic process
- positive regulation of neuron projection development
- regulation of synaptic transmission, GABAergic
- regulation of synaptic transmission, glutamatergic
- negative regulation of action potential
- maternal process involved in female pregnancy
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- spermatogenesis
- response to cocaine
- negative regulation of blood pressure
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- response to nutrient
- response to nicotine
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of blood pressure
- regulation of feeding behavior
- positive regulation of acute inflammatory response to antigenic stimulus
- positive regulation of apoptotic process
- glucose homeostasis
- negative regulation of mast cell activation
- response to lipopolysaccharide
- positive regulation of fever generation
- negative regulation of dopamine secretion
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- growth cone
- cytoplasm
- membrane raft
- actin cytoskeleton
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- identical protein binding
- protein binding
- cannabinoid receptor activity