Tmtc2 Gene Summary [Mouse]
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in calcium ion homeostasis and protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including cranial ganglion; gut; limb segment; musculoskeletal system; and sensory organ. Orthologous to human TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tmtc2 |
| Official Name | transmembrane and tetratricopeptide repeat containing 2 [Source:MGI Symbol;Acc:MGI:1914057] |
| Ensembl ID | ENSMUSG00000036019 |
| Bio databases IDs | |
| Aliases | transmembrane and tetratricopeptide repeat containing 2 |
| Synonyms | 8430438D04RIK, D330034A10Rik, IBDBP1, RGD1309848, transmembrane and tetratricopeptide repeat containing 2, transmembrane O-mannosyltransferase targeting cadherins 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmtc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of Unknown Function (DUF3856)
- TPR repeat
- Tetratricopeptide repeats
- Protein O-mannosyl-transferase TMTC, DUF1736
- enzyme
- protein binding
- tetratricopeptide repeat
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmtc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion homeostasis
- protein O-linked mannosylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannosyltransferase activity
- dolichyl-phosphate-mannose-protein mannosyltransferase activity