Neurog1 Gene Summary [Mouse]
Enables E-box binding activity and chromatin binding activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including inner ear morphogenesis; positive regulation of exit from mitosis; and regulation of neuron differentiation. Located in perikaryon. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; neurogenic placode; and sensory organ. Orthologous to human NEUROG1 (neurogenin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neurog1 |
| Official Name | neurogenin 1 [Source:MGI Symbol;Acc:MGI:107754] |
| Ensembl ID | ENSMUSG00000048904 |
| Bio databases IDs | |
| Aliases | neurogenin 1 |
| Synonyms | AKA, bHLHa6, CCDDRD, Math4C, NEUROD3, neurogenin 1, Ngn1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neurog1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- protein homodimerization
- Helix-loop-helix DNA-binding domain
- basic domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Neurog1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital cranial dysinnervation disorder with absent corneal reflex and developmental delay
role in cell
- expression in
- survival
- migration
- quantity
- generation
- differentiation
- development
- formation
- misspecification
- modification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neurog1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- trigeminal nerve development
- nervous system development
- positive regulation of neuron differentiation
- thorax and anterior abdomen determination
- regulation of muscle organ development
- craniofacial suture morphogenesis
- vestibulocochlear nerve formation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of exit from mitosis
- forebrain development
- exit from mitosis
- genitalia morphogenesis
- genitalia development
- cochlea development
- cochlea morphogenesis
- sensory organ development
- regulation of transcription from RNA polymerase II promoter
- inner ear morphogenesis
- cell fate commitment
- auditory behavior
- mastication
- peristalsis
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- nucleus
- perikaryon
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- chromatin binding
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity