Rab3gap1 Gene Summary [Mouse]
Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in several processes, including excitatory postsynaptic potential; modulation of chemical synaptic transmission; and positive regulation of GTPase activity. Predicted to be located in cis-Golgi network; endoplasmic reticulum tubular network; and excitatory synapse. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain and neural retina. Human ortholog(s) of this gene implicated in Warburg micro syndrome 1. Orthologous to human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab3gap1 |
| Official Name | RAB3 GTPase activating protein subunit 1 [Source:MGI Symbol;Acc:MGI:2445001] |
| Ensembl ID | ENSMUSG00000036104 |
| Bio databases IDs | |
| Aliases | RAB3 GTPase activating protein subunit 1 |
| Synonyms | 1700003B17Rik, 4732493F09Rik, LOC501853, MARTS2, P130, RAB3GAP, RAB3GAP130, rab3-GAP p130, RAB3 GTPase activating protein catalytic subunit 1, RAB3 GTPase activating protein subunit 1, RGD1306487, WARBM1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab3gap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanyl-nucleotide exchange factor
- enzyme binding
- GTPase activator
- protein binding
- Rab3 GTPase-activating protein catalytic subunit
- Rab3 GTPase-activating protein catalytic subunit C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Warburg Micro syndrome type 1
- hereditary disorder
- Warburg Micro syndrome
- Martsolf syndrome type 2
- polymicrogyria
regulates
- RAB18
- neurotransmitter
- GTPase
- hormone
role in cell
- disruption
- organization
- assembly
- disruption in
- paired-pulse facilitation
- priming
- spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum tubules
- Golgi Apparatus
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- cis Golgi networks
- transport vesicles
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab3gap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- camera-type eye development
- regulation of GTPase activity
- positive regulation of autophagic vacuole assembly
- lipid particle organization
- hypothalamus development
- brain development
- regulation of short-term neuronal synaptic plasticity
- establishment of protein localization in endoplasmic reticulum membrane
- positive regulation of GTPase activity
- face morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- extracellular vesicular exosome
- endoplasmic reticulum tubular network
- cytosol
- Golgi apparatus
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding