Slc26a8 Gene Summary [Mouse]
Predicted to enable chloride transmembrane transporter activity and organic anion transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport; oxalate transport; and sulfate transmembrane transport. Predicted to be located in sperm annulus. Predicted to be active in plasma membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in spermatogenic failure 3. Orthologous to human SLC26A8 (solute carrier family 26 member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc26a8 |
| Official Name | solute carrier family 26, member 8 [Source:MGI Symbol;Acc:MGI:2385046] |
| Ensembl ID | ENSMUSG00000036196 |
| Bio databases IDs | |
| Aliases | solute carrier family 26, member 8 |
| Synonyms | AZON, solute carrier family 26 member 8, solute carrier family 26, member 8, SPGF3, TAT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc26a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxalate transporter
- Sulfate permease family
- sulfate transporter
- sulfate porter
- PRK11660
- chloride channel
- high affinity sulphate transporter 1
- protein binding
- chloride transporter
- inorganic anion exchanger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- sperm annulus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc26a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfate transport
- meiotic cell cycle
- spermatogenesis
- cell differentiation
- oxalate transport
- chloride transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- sperm annulus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxalate transmembrane transporter activity
- chloride channel activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- sulfate transmembrane transporter activity