Sst Gene Summary [Mouse]
Enables receptor ligand activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels and somatostatin signaling pathway. Acts upstream of or within regulation of cell migration. Located in extracellular space. Is active in GABA-ergic synapse and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sst |
| Official Name | somatostatin [Source:MGI Symbol;Acc:MGI:98326] |
| Ensembl ID | ENSMUSG00000004366 |
| Bio databases IDs | |
| Aliases | somatostatin |
| Synonyms | Preprosomatostatin, prosomatostatin, SMST, SOM, somatostatin, SRIF, Srih, SS, SST1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Somatostatin/Cortistatin family
- hormone
- receptor agonist activity
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Sst gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- benign neoplasia
- colorectal cancer
- Huntington disease
- schizophrenia
- androgenic alopecia
- experimentally induced seizure
- psychosis
- epileptic seizure
- hyperchlorhydria
role in cell
- activation in
- migration
- expression in
- apoptosis
- accumulation in
- phosphorylation in
- proliferation
- inhibition
- cell cycle progression
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- mossy fiber band
- peptidergic fiber
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- synapse
- secretory granules
- membrane processes
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of cell proliferation
- response to amino acid stimulus
- cell-cell signaling
- digestion
- synaptic transmission
- response to nutrient
- cell surface receptor signaling pathway
- response to xenobiotic stimulus
- response to steroid hormone stimulus
- hyperosmotic response
- induction of apoptosis by hormones
- response to acidity
- regulation of cell migration
- response to organic nitrogen
Cellular Component
Where in the cell the gene product is active
- extracellular space
- neuronal cell body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity