Vip Gene Summary [Mouse]
This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Vip |
| Official Name | vasoactive intestinal polypeptide [Source:MGI Symbol;Acc:MGI:98933] |
| Ensembl ID | ENSMUSG00000019772 |
| Bio databases IDs | |
| Aliases | vasoactive intestinal polypeptide |
| Synonyms | PHM27, vasoactive intestinal peptide, vasoactive intestinal polypeptide, vip/phi27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptide hormone
- G-protein-coupled receptor binding
- hormone
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Vip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac hypertrophy
- rheumatoid arthritis
- osteoporosis
- collagen-induced arthritis
- hypertension
- pulmonary hypertension
- insulin-dependent diabetes mellitus
- psoriasis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
role in cell
- cell death
- growth
- accumulation in
- expression in
- differentiation
- apoptosis
- binding in
- proliferation
- signaling in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- Plasma Membrane
- nerve ending
- perikaryon
- axons
- dendrites
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epinephrine secretion
- G-protein coupled receptor signaling pathway
- regulation of protein localization
- mRNA stabilization
- positive regulation of cell proliferation
- positive regulation of protein catabolic process
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- prolactin secretion
- body fluid secretion
Cellular Component
Where in the cell the gene product is active
- extracellular region
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- peptide hormone receptor binding
- hormone activity