Abt1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and spinal cord motor neuron differentiation. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; ear; early conceptus; genitourinary system; and nervous system. Orthologous to human ABT1 (activator of basal transcription 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abt1 |
| Official Name | activator of basal transcription 1 [Source:MGI Symbol;Acc:MGI:1353636] |
| Ensembl ID | ENSMUSG00000036376 |
| Bio databases IDs | |
| Aliases | activator of basal transcription 1 |
| Synonyms | activator of basal transcription 1, Esf2, hABT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- transcription co-activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- positive regulation of transcription, DNA-dependent
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- small-subunit processome assembly
- spinal cord motor neuron differentiation
- transcription from RNA polymerase II promoter
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nucleolus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- transcription coactivator activity